Autoimmune Disorders|A new therapy for autoimmune disorder|Autoimmune Disorders Cure|Autoimmune diseases

     Autoimmune Disease Treatment In India

The immune system is a collection of special cells and chemicals that fight infection-causing agents such as bacteria and viruses. An autoimmune disorder occurs when a person's immune system mistakenly attacks their own body tissues.

Autoimmune disorders are broadly grouped into two categories- 'organ-specific' means one organ is affected, while in 'non-organ-specific' disorders, multiple organs or body systems may be affected.

There are around 80 different autoimmune disorders ranging in severity from mild to disabling, depending on which system of the body is under attack and to what degree. For unknown reasons, women are more susceptible than men, particularly during their childbearing years. It is thought that sex hormones may be at least partly responsible. There is generally no cure, but the symptoms of autoimmune disorders can be managed.

Types of Autoimmune Disease-

The most common autoimmune diseases are:

Diabetes:

The pancreas releases the insulin hormone, which aids in the regulation of blood sugar levels. In this disease, the immune system attacks and destroys insulin-producing cells in the pancreas.

Rheumatoid Arthritis (RA): 

In rheumatoid arthritis, the immune system attacks the joints. This attack causes stiffness in the joints, redness, soreness, and warmth.

Psoriasis or Psoriatic Arthritis:

Skin cells usually grow and then shed when they are no longer required. In psoriasis, skin cells multiply too quickly. This causes the extra cells to build up and form scaly, red patches known as scales or plaques on the skin.

Multiple Sclerosis: 

This disease damages the myelin sheath, which is the protective coating that borders the nerve cells. Harm to the myelin sheath disturbs the transmission of messages between the brain and body.

Systemic Lupus Erythematosus (Lupus): 

Even though lupus was first described as a skin disease because of the rash it produces, it hampers many organs, including the heart, brain, joints, and kidneys. Read More...

Types of Bone Marrow Transplants | Best Bone Marrow Transplantation in India |Bone Marrow Transplant Procedure & Types

What are the different types of BMT?

Bone Marrow Transplant (BMT) actually means an infusion of stem cells (collected either from bone marrow or peripheral blood or cord blood) into the recipient. There are different types of bone marrow transplants depending on the donor.

The different types include the following:

Autologous transplant – (Self-Donated)

• Allogeneic transplant – uses blood-forming cells donated by someone else
• Allogeneic (Donor) Transplants Using Matched Sibling
• Allogeneic Transplants Using Unrelated Donors
• Allogeneic Transplants Using Haploidentical (Half-Matched) Donors
• Allogeneic Transplants Using Umbilical Cord Blood

Some other Types of Transplants :

• Syngeneic BMT: 

A syngeneic transplant is an allogeneic transplant from an identical twin. Identical twins are considered a complete genetic match for a transplant. In cases where the donor is the identical twin of the patient, the transplant is essentially like an autologous transplant, as the cells are genetically identical.

• Mini Transplant: 

Mini transplant is termed coined on the basis of conditioning regimen before transplant (“Non-Myeloablative” or, more accurately, “Reduced-Intensity Conditioning” transplant). This type of transplant makes the procedure safer in patients of older age or with pre-existing health problems. Read More...

Definition of bone marrow Transplant Abroad|

What is Bone Marrow?

A part of bones called “bone marrow” create blood cells. Marrow is the soft, spongy tissue inside your bones. Bone marrow produces blood cells called “hematopoietic” stem cells. These cells will develop into many different kinds of cells. They can turn into more bone marrow cells. Or they can turn into any type of blood cell.

Certain cancers and different types of diseases keep hematopoietic stem cells from developing normally. If they’re not normal, neither are the blood cells that they make. A stem cell transplant provides you new stem cells. The new stem cells can make new, healthy blood cells. It creates the following parts of the blood.

• Red Blood Cells: which carry oxygen and nutrients throughout the body.
• White Blood Cells: which fight infection.
• Platelets: which are responsible for the formation of clots.

What is Bone Marrow Transplant?

Bone Marrow Transplant (BMT) is a special therapy for patients with certain cancers or other diseases. A Bone marrow transplant involves taking cells that are normally found in the bone marrow (stem cells), filtering those cells, and giving them back either to the donor (patient) or to another person. The goal of BMT is to transfuse healthy bone marrow cells into a person after his or her own unhealthy bone marrow has been treated to kill the abnormal cells.

A bone marrow transplant also called a stem cell transplant, is a treatment for some types of cancer. For example, you might have one if you have leukemia, multiple myeloma, or some types of lymphoma. Doctors also treat some blood diseases with stem cell transplants.

There are many different types of blood and bone marrow cancer. Here are a few:

Multiple Myeloma . 

This is the most common. It affects plasma cells. These are white blood cells that help fight infection and disease. In multiple myeloma, cancerous plasma cells push out normal, healthy ones and destroy or weaken your bones.

Lymphomas. 

These usually begin in lymph nodes, but they can also affect the bone marrow. Non-Hodgkin’s lymphoma starts in the lymphocytes, a type of white blood cell. White blood cells are part of the body's immune system.

Leukemia. 

If you have this type of blood cancer, your body makes abnormal blood cells. These abnormal cells crowd the bone marrow so there is less room for healthy blood cells. Usually, it forms in the white blood cells, but it can happen in other types of cells, too. It can be either fast-growing (acute) or slow-growing (chronic). There are many types of leukemia. All of them have different treatments.

Childhood Leukemia . 

This is the most common form of cancer in children and teens. About 3 out of every 4 childhood leukemias are acute lymphocytic leukemia. This starts in the bone marrow from early forms of white blood cells and progresses quickly. The rest are usually acute myeloid leukemia. This type of cancer starts in another early form of blood cell and can move quickly into the blood and spread to other parts of the body. Read More...

Myelodysplastic syndromes|Signs & Symptoms|MDS Symptoms and Diagnosis

Signs & Symptoms of Myelodysplastic Syndrom

Myelodysplastic syndromes are a group of disorders caused by poorly formed blood cells or ones that don’t work properly. Myelodysplastic syndromes result from something amiss in the spongy material inside your bones where blood cells are made (bone marrow).

Treatment for myelodysplastic syndromes usually focuses on reducing or preventing complications of the disease and its treatments. In some cases, treatment might involve chemotherapy or a bone marrow transplant.

The main feature of myelodysplastic syndromes (MDS) is that they cause low blood cell counts. Sometimes this is found on blood tests, even before symptoms appear. In other cases, symptoms related to shortages of one or more types of blood cells (cytopenias) are the first sign of MDS:
Having too few red blood cells (anemia) can lead to feeling tired, dizzy, or weak, as well as shortness of breath and pale skin.

Not having enough normal white blood cells (leukopenia), especially cells called neutrophils (neutropenia), can lead to frequent or severe infections.

Having too few blood platelets (thrombocytopenia) can lead to easy bruising and bleeding. Some people have frequent or severe nosebleeds or bleeding from the gums.

People with MDS may experience the following symptoms or signs. Sometimes, people with MDS do not have any of these changes. Or, the cause of a symptom may be a different medical condition that is not MDS.

• Fatigue
• Weakness
• Easy bruising or bleeding
• Fever
• Bone pain
• Shortness of breath
• Frequent infections Read More...

Fanconi anemia Treatment india | Bone Marrow Transplant Abroad

What is Fanconi anemia?

Fanconi anemia is a rare and serious inherited blood disorder that leads to bone marrow failure. It prevents bone marrow from making enough new blood cells for the body to work properly. Fanconi anemia can also cause bone marrow to make faulty blood cells. This can lead to serious health problems such as leukemia, a type of blood cancer.

Fanconi anemia is a type of aplastic anemia – a condition that causes the blood to have a lower than a normal number of blood cells. In Fanconi anemia, the bone marrow does not make enough or stops making all three types of blood cells – red blood cells (to carry oxygen), white blood cells (to fight infection) and platelets (to help blood clot).

Although Fanconi anemia is a blood disorder, it can also affect many of the body’s other organs, tissues, and systems. Children who inherit Fanconi anemia are at higher risk for birth defects and for developing certain cancers and other serious health conditions.

Fanconi anemia is different than Fanconi syndrome, a condition that affects the kidneys.

Fanconi anemia is often diagnosed at birth or soon after because it affects the way your bone marrow produces blood cells. When you don’t have a sufficient number of blood cells you’ll begin to experience the following:

Aplastic Anemia

Aplastic anemia is characterized by a lack of energy due to low numbers of red blood cells, which help to oxygenate your blood. The symptoms of anemia include dizziness, headaches, and an inability to keep your hands and feet warm.

Birth Defects

Certain types of birth defects will indicate that your infant has FA, including:

• Bone defects, especially involving the thumbs and arms
• Eye and ear defects
• Skin discoloration
• Kidney problems
• Congenital heart defects

Developmental Problems

• Developmental problems can include:
• Low birth weight
• Poor appetite
• Delayed growth
• A smaller-than-normal height
• A smaller-than-normal head size
• Intellectual disability

Symptoms in Adults

Adults who are diagnosed later in life will usually experience a completely different set of symptoms. The symptoms in adults will usually affect the sexual organs or the reproductive system. The symptoms in women include:

• Periods that occur later than normal
• Fertility issues
• Frequent miscarriages
• Early menopause
• Smaller-than-normal genitals

Men with FA may experience fertility issues and have smaller-than-normal genitals.

Read More...

Symptoms of leukemia india| Bone Marrow Transplant Abroad

Symptoms of leukemia india| Bone Marrow Transplant Abroad

Leukemia symptoms are often mild at first but slowly worsen over time. Some people with chronic (slow-growing) leukemia don’t notice any symptoms at all, and only find out they have the disease when they have a routine blood test.

The symptoms of leukemia depend on how many abnormal white blood cells are in the body, and where they collect.

In cases of acute (fast-growing) leukemia, abnormal white blood cells multiply rapidly and spill out from the bone marrow into the bloodstream, crowding out healthy blood cells, which can no longer do their job properly.

In chronic leukemia, abnormal white blood cells fail to die, and slowly build up in the bloodstream, bone marrow, and other organs.

Common symptoms of leukemia

Some of the more common symptoms of leukemia include:

• tiredness
• anemia (paleness, weakness, breathlessness)
• repeated infections, for example, mouth sores, infected cuts, and scratches
• prone to bruising and bleeding.

Other symptoms of leukemia

Less common symptoms of leukemia can include:

• bone pain
• chest pain
• painful or swollen gums
• skin rashes
• headaches or eyesight problems
• vomiting
• enlarged spleen or lymph glands

If you notice any of these symptoms, it doesn’t mean you have leukemia, but it’s a good idea to see your doctor for a check-up. Read More...

Causes Of Aplastic Anemia | Bone Marrow transplant Abroad

Causes Of Aplastic Anemia | Bone Marrow transplant Abroad

What is Aplastic anemia?

Aplastic anemia is a rare disorder in which the bone marrow fails to produce enough blood cells. This happens because the normal blood-forming cells (stem cells) are replaced by abnormal fat cells.

A rare and serious condition, aplastic anemia can develop at any age. Aplastic anemia may occur suddenly, or it can occur slowly and get worse over a long period of time. Treatment for aplastic anemia may include medications, blood transfusions or a stem cell transplant, also known as a bone marrow transplant.

Symptoms

• Aplastic anemia symptoms may include
• Fatigue
• Shortness of breath with exertion
• Rapid or irregular heart rate
• Pale skin
• Frequent or prolonged infections
• Unexplained or easy bruising
• Nosebleeds and bleeding gums
• Prolonged bleeding from cuts
• Skin rash
• Dizziness
• Headache

Causes

Aplastic anemia develops when damage occurs to your bone marrow, slowing or shutting down the production of new blood cells. Bone marrow is a red, spongy material inside your bones that produces stem cells, which give rise to other cells. Stem cells in the bone marrow produce blood cells — red cells, white cells, and platelets. In aplastic anemia, the bone marrow is described in medical terms as aplastic or hypoplastic — meaning that it's empty (aplastic) or contains very few blood cells (hypoplastic).

• Radiation and chemotherapy treatments.
• Exposure to toxic chemicals.
• Use of certain drugs. 
• Autoimmune disorders.
• A viral infection.
• Pregnancy.
• Unknown factors.
• Confusion with myelodysplastic syndrome

Aplastic anemia can be mistaken for a condition called myelodysplastic syndrome. In this group of disorders, the bone marrow produces new blood cells, but they're deformed and underdeveloped. The bone marrow in myelodysplastic syndrome is sometimes called hyperplastic — meaning that it's packed with blood cells. But some people with the myelodysplastic syndrome have an empty marrow that's difficult to distinguish from aplastic anemia.

Prevention

There's generally no prevention for most cases of aplastic anemia. Avoiding exposure to insecticides, herbicides, organic solvents, paint removers, and other toxic chemicals may lower your risk of the disease.
 Read More....

Lymphoma Treatment in India at Affordable Cost | BMT Abroad

What Is Lymphoma?

Lymphoma is cancer that begins in infection-fighting cells of the immune system, called lymphocytes. These cells are in the lymph nodes, spleen, thymus, bone marrow, and other parts of the body. When you have lymphoma, lymphocytes change and grow out of control.

There are two main types of lymphoma:
Non-Hodgkin: Most people with lymphoma have this type.
Hodgkin
Causes

Scientists don't know what causes lymphoma in most cases.

• You might be more at risk if you:
• Are in your 60s or older for non-Hodgkin lymphoma
• Are between 15 and 40 or older than 55 for Hodgkin lymphoma
• Are male, although certain subtypes may be more common in females
• Have a weak immune system from HIV/AIDS, an organ transplant, or because you were born with an immune disease
• Have an immune system disease such as rheumatoid arthritis, Sjögren's syndrome, lupus, or celiac disease
• Have been infected with a virus such as Epstein-Barr, hepatitis C, or human T-cell leukemia/lymphoma (HTLV-1)
• Have a close relative who had lymphoma
• Were exposed to benzene or chemicals that kill bugs and weeds
• Were treated for Hodgkin or non-Hodgkin lymphoma in the past
• Were treated for cancer with radiation

Symptoms

• Warning signs of lymphoma include:
• Swollen glands (lymph nodes), often in the neck, armpit, or groin that are painless
• Cough
• Shortness of breath
• Fever
• Night sweats
• Fatigue
• Weight loss
• Itching

Many of these symptoms can also be warning signs of other illnesses. See your doctor find out for sure if you have lymphoma.

Read more...

Leukemia Cancer Treatment India with Bone Marrow Transplant Abroad

Leukemia Cancer Treatment India with Bone Marrow Transplant Abroad

Leukemia is the name given to a group of cancers that develop in the bone marrow. Under normal conditions, the bone marrow contains a small number of healthy immature blood cells, sometimes called blast cells. These immature blood cells mature and develop into red cells, white cells and platelets, which are eventually released into the bloodstream.

Leukemia originates in developing blood cells, which have undergone a malignant (cancerous) change. Instead of maturing properly, these cells grow and multiply in an uncontrolled fashion and interfere with normal blood cell production in the bone marrow.

There are several different types and subtypes of leukemia-

Acute lymphocytic leukemia (ALL)
Acute lymphocytic leukemia (ALL)
Chronic lymphocytic leukemia (CLL)
Chronic myelogenous leukemia (CML)

Common symptoms of leukemia-

tiredness
anemia (paleness, weakness, breathlessness)
repeated infections, for example, mouth sores, infected cuts, and scratches
prone to bruising and bleeding.

Other symptoms of leukemia-
bone pain
chest pain
painful or swollen gums
skin rashes
headaches or eyesight problems
vomiting
enlarged spleen or lymph glands

If you notice any of these symptoms, it doesn’t mean you have leukemia, but it’s a good idea to see your doctor for a check-up.

Read more...